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Notably, clinician consensus on obesity as a chronic disease remains limited, with less than half routinely documenting it as such

The most transformative results often emerge between months 3-6, where individuals can experience substantial weight reduction, often surpassing outcomes seen with other medications

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In the field of IMDs, betaine has been used for more than 30 years in pyridoxine non-responsive cystathionine beta-synthase (pnrCBS) and cobalamin C (cblC) deficiencies, to lower hyperhomocysteinemia and alleviate neurological impairment 44