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14.3 Combination Therapy Use of RYBELSUS in Patients with Type 2 Diabetes Mellitus Combination with Metformin In a 26-week trial (Trial 2, NCT02863328), 822 adult patients with type 2 mellitus diabetes were randomized to RYBELSUS 14 mg once daily or empagliflozin 25 mg once daily, all in combination with metformin

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Low BMD at these sites strongly correlates with higher likelihood of osteoporotic fractures (e.g., hip fractures, vertebral fractures)

Patients with a history of pancreatitis or uncontrolled gallstone disease should avoid these therapies

& Chang, C.-C