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Genes linked to vitiligo pathogenesis are categorized into five groups: transcription factors/co-regulators, adaptive immunity, innate immunity, cellular signaling/adaptor proteins/receptors, and nonimmune genes (Jin et al., 2016

ACSL4 is the key enzyme catalyzing the activation of long-chain fatty acids in ferroptosis, and its aberrant expression is closely associated with a number of biological responses, including steroidogenesis, inflammatory responses, cell death, and immune activation responses (54)

The nasal cavities of the nose are anatomically divided into three regions: 1) Vestibular region: located just inside the nostrils, has a limited surface area resulting in filtration of inhaled particles and minimal drug absorption