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Hydrophobic peptides or peptides rich in basic amino acids such as arginine, lysine or histidine may require an acidic first step solvent to support full dissolution

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To determine whether dysregulated hepatic glutathione homeostasis and TNF can synergistically contribute to hepatocyte death, we performed cell culture studies using both human hepatoma cells and mouse non-transformed hepatocytes

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doi: 10.1007/s40257-018-0409-y