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If you know anything about the history of medicine, its littered with examples like this

This little spot treatment from Peter Thomas Roth combines 10 percent tetrahexyldecyl ascorbate with vitamin E and ferulic acid in a concentrated spot treatment to really target acne scars

J Phys Chem B 126:36593672

10.1186/s12958-020-00613-z 134 ZhouL

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Interestingly, these effects were more pronounced in the high-dose APLA group compared to PLA, suggesting dose- and type-dependent neurotoxicity (Qian et al., 2025)