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Its bioavailability is low, with less than 10% reaching plasma and tissues

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[Abstract] Cell Signal

Treatment of cultured human islets with exendin-4 (50 nM), a GLP-1 receptor agonist, suppressed the expression of inflammatory genes such as NF B1(p105), NF B2(p100), RelA (also termed p65), TNF receptor superfamily member 1A, and receptor-interacting serine/threonine kinase 2