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High levels of this hormone may have harmful effects in the heart, including as mechanism of cardiac remodeling, meaning enlargement

Tang Q, Zheng G, Feng Z, Chen Y, Lou Y, Wang C, et al

This trend has the potential to increase further as the use of canonical ICIs (anti-CTLA-4 and anti-PD-1/PD-L1), alone or in combination, is increasing exponentially and nearly 50% of patients treated will experience some form of irAEs (278)

Glucagon receptor agonism: Glucagon is a novel element of the therapy that typically raises blood sugar levels in your body, but its agonism promotes increased energy expenditure and fat burning

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