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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

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"So it's very challenging," Yacawych says, "to be able to separate these side effects, like nausea, from GLP-1's intended effects, like weight loss." A possible workaround came from a team led by Ernie Blevins of the University of Washington

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GSH depletion significantly elevates intracellular oxidative stress, which can profoundly influence the progression and therapeutic outcomes of various diseases (199202)

We chose to make all transport rates linear and adjusted them so that the measured APAP, APAP-S, APAP-G, and NAPQI-GSH concentrations in the plasma and the urine were as measured in the literature[4, 6, 11, 3032]