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Low dose (0.1 mg/kg/d) can promote fat breakdown, reduce serum triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C)

Patients with chronic low-protein intake (common in restrictive diets) often present with subclinical methionine deficiency, which manifests as elevated liver enzymes and impaired VLDL synthesis

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Patients with Leber's Disease: Vitamin B12 levels may exacerbate optic nerve atrophy

Most experiments were performed in HCT-116 cells, with selected validation in HT-29 cells, and the findings may not be generalizable to the metabolic heterogeneity of colorectal cancer

C., Voors, A