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Around7%of Caucasian people have CYP2D6 enzymes that are less active than normal as a recessive trait, and doctors refer to these people as poor metabolizers. If you are a poor metabolizer of CYP2D6, tramadol will take longer than expected to be cleared from your body

About Zepbound (tirzepatide) injection1 Zepbound (tirzepatide) injection is FDA-approved as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity (BMI 30 kg/m2), or overweight (BMI 27 kg/m2) with at least one weight-related comorbid condition

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For more on how Zepbound compares to other weight loss medications, see our Zepbound alternatives guide

A leave-on product has more staying power

Consider what inadequate monitoring can miss: Undiagnosed kidney disease