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It is primarily caused by autoimmune destruction of the gastric parietal cells, leading to a deficiency in Intrinsic Factor and, consequently, a failure to absorb vitamin B12

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Indirect effects are mediated mainly through IGF-1 (insulin-like growth factor 1), which is produced in the liver and other tissues in response to GH boost

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In fact, since protected regions exchange more slowly than exposed, flexible regions, protein secondary and tertiary structure can be deduced from the rate at which backbone amide protons exchange with solvent deuterium