Their anti-inflammatory properties and protective effects against damage caused by harmful agents in macrophages were also evaluated
Limitations One of the limitations of the current study was the small sample size
However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention
Comparative Table: Glutathione Injections vs
It is not approved by the FDA for clinical use
For instance, supplementation with antioxidants like N-acetylcysteine (NAC) and vitamin E in the diet can accelerate the progression of primary lung tumors in Kras2 LSL/+ (K) mice [114]