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Key Takeaways Vitamin B12 doesnt give you energy on its own

Some may experience minor irritation at the injection site

Additionally, conditions such as pernicious anemia, gastrointestinal disorders, or even aging can impair B12 absorption

Blouw, B

For human relevance, sufficient published, peer-reviewed controlled human studies and regulatory review would be necessary

Metanx increases production of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase (eNOS), which, theoretically, should counteract eNOS uncoupling, generation of superoxide, superoxide-induced upregulation of inducible nitric oxide synthase (iNOS), and peroxynitrite formation