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For some people, pursuing weight loss can be harmful, for instance by leading to weight cycling or increasing the risk of developing an eating disorder
The GLP-1 and GIP tolerance you built on tirzepatide is relevant, but the glucagon component is a wild card
It is precisely this slowing of gastric emptying that contributes to the most commonly reported adverse effects: gastrointestinal symptoms
This isnt the full list of side effects for phentermine/topiramate ER
Additionally, microglia, which are primary targets of the GLP-1R signal transduction pathway in the spinal cord, exhibit reduced activation and decreased expression of pro-inflammatory cytokines following exendin-4 treatment, suggesting therapeutic potential in monophasic EAE [113]
But the FDA has never approved phentermine for long-term continuous use, and the data supporting extended protocols is thin
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