MMP/TIMP Rebalancing
In many solid tumors, extracellular matrix deposition, cancer-associated fibroblast activation and elevated interstitial fluid pressure restrict the movement of nanoparticles from perivascular regions into deeper tumor tissue [14, 17, 30, 32, 34]
The modulatory effects of GGT-mediated prooxidant reactions could contribute to the resistance phenotype of GGT-expressing cancer cells by regulating both signal transduction pathways involved in proliferation/apoptosis balance, as well as by inducing protective adaptations in the pool of intracellular antioxidants
Microinfusion session day
Z., Zheng, S
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