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Semaglutide functions as a GLP-1 receptor agonist, selectively binding to and activating GLP-1 receptorsthe primary targets of native GLP-1

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Additionally, while some studies raise concerns about GLP-1s increasing depression, anxiety, and suicidal thoughts, other studies point in the opposite direction, noting a decrease in depressive symptoms, improved cognitive function, and an increase in feelings of self-mastery

There is no direct evidence to show the combination is safe or unsafe

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