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Obesity-associated metabolic disease Rapidly changing lifestyle, accompanied by consumption of excess energy in the form of a calorie-rich high-fat diet, lower voluntary activity, and increased exposure to environmental pollutants, have led to an exponential rise in noncommunicable metabolic diseases [1]

GSTZ1-1 is a bifunctional enzyme that, acting as maleylacetoacetate isomerase, is also involved in the metabolic degradation of phenylalanine and tyrosine 83

This process of erythrophagocytosis leads to the breakdown of hemoglobin and the oxidation of heme in macrophage lysosomes

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Young LA, Buse JB, Weaver MA, Vu MB, Mitchell CM, Blakeney T, et al