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Anemia may cause weakness, fatigue, dizziness, and a rapid heartbeat

A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

Alternatively, or in addition, this may be its essential penetration of both the epineurium and neuronal membrane during the action for the time that a local anesthetic remains near neural fibers

The evidence is clear: for most patients, high-dose oral supplements are as effective as injections

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