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Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline

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These diabetes-specific results mirror the pattern seen with CagriSema in REDEFINE 2, though direct comparison requires caution because the trial populations and designs differed

Weisshof R, Ollech JE, El Jurdi K et al

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