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Dysbiosis of the gut often occurs in aging or estrogen-deficient situations and results in the disturbance of estrogen metabolism and IGF-1 production

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These include the derivatives of D-Nle-X-Ile- (6) amino-hexanoic amide, an AngFV-based analog family, where X= Tyr, Cys, Trp, and Met

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They rely on techniques like magnetic guidance, receptor-mediated transport, ultrasound, as well as computed tomography (CT), Near InfraRed (NIR) and Magnetic Resonance (MR) imaging (18), photodynamic therapy (PDT) (19) and radiosensitization (20)