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Patients with chronic kidney disease, cardiovascular diseases, and those with obesity related complications such as moderate to severe obstructive sleep apnea (OSA) should not use microdoses of GLP-1 medications

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It tends to peak around days three through seven

So it was very important for our chain of thought and decision early on that we actually knew that GLP-1 had these separate effects and that they could work in the brain and have a separate effect on well-known pathways in the brain

The decision about which weight loss option is appropriate should always be made in partnership with your doctor, who will consider several important factors, including: Your overall health Medical history Current medications The amount of weight youre aiming to lose Your tolerance for certain treatments Always talk with your doctor when exploring effective weight loss options