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Given the physiological importance of SLC25A39, therapeutic targeting warrants cautious evaluation to avoid systemic toxicity arising from interference with normal mitochondrial metabolism

Hydroxocobalamin 20 mg/ml Injection Solution is a sterile, preservative-free solution of hydroxocobalamin, a form of vitamin B12, contained in a small glass container

Take intravenous infusion in 45-60 minutes

Further provided herein are methods comprising the administration of said otic formulations or compositions

Most of it is broken down in the gut before reaching systemic circulation

A lower, more conservative dose might require a longer cycle to achieve the same cumulative effect as a higher dose over a shorter period