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Results depend on pigmentation severity and concentration.

In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

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According to a 2015 study, the rash typically starts on the upper trunk but does not spread to the palms or soles of the feet

10.1038/s41467-022-33349-y 93 YusufH

It may have selective advantages for certain phyla and disadvantages for other ones (163)