4547 The effect of metformin is also supported by a study done by Shaw et al on mice given a high-fat diet, where deletion of gene LKB1 (Liver Kinase B1), which is a crucial enzyme phosphorylating the catalytic AMPK domain led to the deactivation of AMPK leading to elevated glucose levels, hence nullifying the glucose reducing metformin effect
It may be prescribed alone or combined with other medications such as bupropion (as in the branded combo Contrave), metformin, or GLP-1 medications like semaglutide or tirzepatide
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At worst, nothing noticeable at all
