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Epithelial-mesenchymal transition of cultured rat neonatal hepatocytes is differentially regulated in response to epidermal growth factor and dimethyl sulfoxide

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FIGURE 9 5.3.5 ROS promotes UPS-mediated acceleration of protein degradation The ubiquitin-proteasome system (UPS) is the primary protein degradation machinery in eukaryotic cells, responsible for removing misfolded, damaged, or excess proteins to maintain proteostasis and regulate key cellular processes including cell cycle and immune signaling ( ROS indirectly accelerate UPS-mediated proteolysis by increasing intracellular calcium levels, activating calpains, and promoting cytoskeletal disassembly

Orthopedic surgeons frequently perform superficial biopsies to evaluate abnormalities before surgical planning