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After 68 weeks, weight loss was higher with one-weekly subcutaneous semaglutide 2.4 mg compared with once-daily liraglutide 3.0 mg ( 15.8% vs

Combining retatrutide with insulin or sulfonylureas significantly increases the risk of hypoglycaemia and may require dose adjustments

It removes water under controlled low temperature and low-pressure conditions

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Clinicians managing these presentations often run longer initial courses and then taper to a maintenance frequency, such as three to four times per week, before eventual discontinuation pending symptom assessment

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