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3 The absorption rate of a 500 mcg B12 dose is only around 2%, while a 1000mcg dose is around 1.3%

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Some researchers also track NAD+ metabolite levels via urinary nicotinamide excretion to confirm functional NNMT inhibition, though this is not standard practice

IM administration may provide the most robust response in clinical scenarios requiring rapid or substantial metabolic correction

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10.1016/s0928-4257(99)00124-2 111 SikiricP.MarovicA.MatozW.AnicT.BuljatG.MikusD.et al (1999c)