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If pancreatitis is confirmed, the treatment should not be resumed, and GLP-1 RAs should not be started in patients with a history of pancreatitis [128]

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In that case, due to its cost-effective advantage and potential benefits, metformin should still be considered as a basic therapy for older T2DM patients with a high risk of MACE or amyloid formation

Xavier, R

Those already using metformin or berberine are generally advised in community sources to consider a lower MOTS-c dose with closer monitoring consult a clinician

The outcomes are also meaningfully different in scale