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EMPA-REG Kidney Visual Abstract While empagliflozin was the first out with a CVOT, canagliflozin was the first to complete a kidney-focused flozin trial, CREDENCE, which convincingly answered any doubts from the earlier trials

The AUC ratio was 0.97 (90% CI: 0.901.04)

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Maquart F X, Bellon G, Chaqour B, et al

Many oxidative electrophilic PTMs (e.g., cysteine oxidation at Cys151, Cys273 and Cys288) promote Nrf2 activation, leading to antioxidant gene induction, reduced ROS burden and limited TXNIP released from TRX thereby suppressing NLRP3 assembly

This is the expert-level detail that separates inconclusive data from a genuine breakthrough