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GLP-1 receptor agonists are a class of medications originally developed to manage type 2 diabetes

Animal studies in diet-induced obese rats show tesofensine (2.0mg/kg) produces marked weight reduction accompanied by strong hypophagic responses

The same research group also published a study in older adults with HIV showing similar benefits, including reduced oxidative stress and improved mitochondrial fatty acid oxidation (Kumar et al., Antioxidants, 2020) [30]

Quick Answer: Weight loss injections like semaglutide and tirzepatide can be used with IBS, as IBS is not a contraindication, but require careful evaluation based on IBS subtype and symptom severity