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Patients who have rheumatoid arthritis in the cervical spine (neck) can have a dangerous laxity (looseness) in the ligaments around the first two cervical vertebrae

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UPR is associated with three ER transmembrane receptors: protein kinase R-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6) and inositol-requiring kinase 1 (lRE1) in mammalian cells (Szegezdi et al., 2006)