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Preparation matters: keep your compounded semaglutide refrigerated until 30 minutes before injection, choose a clean injection site (abdomen, thigh, or upper arm), and rotate locations weekly to prevent irritation

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Extending the interval to 10 days creates a gap where medication levels drop below therapeutic thresholds, potentially reducing appetite suppression, metabolic benefits, and weight loss consistency

Dose reduction of these concurrent medications may be necessary

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Semaglutide slows gastric emptying by 20 to 30 percent, extending the time food stays in your stomach by roughly 20 to 30 minutes per meal