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TRIUMPH-4: Breakthrough in Osteoarthritis and Extreme Weight Loss In December 2025, the results of the TRIUMPH-4 trial (NCT05869903) were released, marking the first successful Phase 3 readout for retatrutide

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Metabolic Changes from Ozempic: The drug alters how the body stores and burns fat, which can lead to uneven fat loss, especially in the face

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