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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

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Zhang Y., Han P., Wu N., He B., Lu Y., Li S., Liu Y., Zhao S., Liu L., Li Y

Berberine can help some people and may support metabolic markers, but its average weight-loss effects are usually smaller and more variable

[ CrossRef ] [ Google scholar ] [ PubMed ] Milanovic M, Fan DNY, Belenki D, Dbritz JHM, Zhao Z, Yu Y, et al

Additionally, upregulated Ras-RAF-MEK pathway expression may enhance cancer cell sensitivity to ferroptosis by modulating VDAC2/3 function and increasing ROS generation (40)