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Although research is still ongoing, the changes in weight, appetite, and body fat percentage may influence estrogen levels and ovulation patterns

DHT can act in an autocrine fashion on the stromal cells or in paracrine fashion by diffusing into nearby epithelial cells

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While the discontinuation literature is still limited, recent meta-analyses indicate that weight regain begins early and can occur even with continued lifestyle support [123, 124]

Anyone who says with certainty that potential long-term effects of these drugs in children or adolescents does not understand the power of these medications and their potential for altering growth and development of behavior, metabolism and physiology. Ultimately, the medications can be helpful for some adolescents but data still indicates that in many cases, a healthy weight can be achieved through regular exercise and lifestyle changes, such as diet

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