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The 500 Dalton rule favors GHK-Cu penetration (molecular weight roughly 340 Da), but the hydrophilic copper chelate reduces actual dermal delivery without a penetration-enhancing vehicle

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If experiencing severe, persistent upper abdominal pain (especially if radiating to the back) with or without vomiting, they should stop taking the medication immediately and seek urgent medical care, as these may be signs of pancreatitis