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The goal is to find the lowest effective dose that achieves the desired outcomes, whether that is primarily weight loss, inflammation reduction, or both

Many people regain 50% or more of lost weight within 12 months after stopping, which is why ongoing therapy or robust lifestyle changes are critical for long-term success

MT1 as afamelanotide in the EPP trials reliably induced measurable pigmentation, but the comparison population (fair-skinned EPP patients with Fitzpatrick types I to II) is not representative of recreational tanning use

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