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The peptide demonstrates ability to reduce production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), while promoting anti-inflammatory responses

For example, chitosan-based PcDNA3.1-dsNKG2D-IL-21 plasmid nanoparticles were prepared by linking a two-gene fragment encoding NKG2D and the extracellular domain of interleukin (IL)-21 gene and inserting into the pcDNA3.1 plasmid, which can delay tumor growth by activating NK cells in vivo after tumor tissue accumulation (87)

Trends in regenerative medicine: repigmentation in vitiligo through melanocyte stem cell mobilization

Ferroptosis-mediated Inflammation promotes pulmonary hypertension

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