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Lancet 1976;2, 1403, doi:10.1016/s0140-6736(76)91936-x

Sirtuins are a particularly interesting target for such drugs, since activation of these NAD-dependent deacetylases extends lifespan in some animal models

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This allows them to rebuild structures that have been damaged by injury or degeneration

GSH can also serve as a substrate for S-glutathionylation of proteins in the presence of small redox enzyme glutaredoxins (GRX), which also utilizes GSH as a cofactor ( Figure 1 )

150 mcg subQ for 1-2 weeks, then 300 mcg