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Therefore, inhibitors combination against these antioxidant systems with such prooxidant properties is required to elevate the intracellular ROS concentrations within tumor cells and it may be crucial to devastate the antioxidant systems beyond the threshold of toxicity level
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For example, dihydroartemisinin, parthenolide, oridonin, triptolide, and oleanolic acid have been confirmed to affect the ferroptosis process through different pathways (Guo J
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