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Retatrutide dramatically reduces hepatic fat content and metabolic inflammation upstream of fibrosis

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Any potentially detrimental direct effects of GLP-1RAs on PDAC progression must be considered concurrently with mediating benefits

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They mimic the effects of the natural hormone (GLP-1) that regulates appetite, digestion and blood sugar levels

Whilst the early evidence for retatrutide liver fat reduction is scientifically promising, patients are best served by working within established NHS pathways and awaiting the outcome of robust Phase 3 trial data and formal regulatory review before drawing firm conclusions about this emerging therapy