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For musculoskeletal, joint, and systemic inflammation indications, the subcutaneous injection is the clinically preferred route

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When the other structures in the knee are still intact and one cannot straighten their knee, commonly this is due to pain and swelling causing the hamstrings to go into spasm or pain with knee extension, which limits the ability to straighten ones leg with an MCL tear

The vial size you choose depends on your dosing protocol and how long you want a single vial to last

I have gotten B-12 shots for years and decided to to get the skinny shot