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The following GLP-1 (glucagon-like peptide-1) receptor agonists are FDA-approved for weight loss:[ref] Retatrutide is a GLP-1/GIP/GCG triple agonist that is currently in trials for weight loss and diabetes, showing promise for weight loss without muscle loss (2026)

Mechanistic work suggests that tri-agonist signaling may influence several components of glucose regulation, including insulin secretion pathways, hepatic glucose handling, and peripheral metabolic signaling

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Diets high in whole, minimally processed foods help support this natural response, while highly processed diets may blunt GLP-1 activity over time, Bannan explains

Diabetes Care 36 , 24892496 (2013)