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In a network meta-analysis of randomized controlled trials (RCTs), all SGLT2 inhibitors (SGLT2is) used as monotherapy were found to be significantly more effective than placebo in reducing HbA1c levels from baseline (mean differences ranged from 0.59 to 1.23%), increasing the proportion of patients achieving target HbA1c levels (odds ratios ranged from 2.18 to 3.45), and reducing mean body weight (mean differences ranged from 1.63 to 3.00 kg) (64) (Grade A)

Some patients may be on the medication for several months or longer, depending on their health goals and how they respond to the drug

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