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A total of 1000 bootstrap replicates were assessed and the 95% confidence intervals for each parameter were calculated using the 2.5th and 97.5th percentile values from the distribution of bootstrap parameter values

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The cortisol elevation is mediated through stimulation of hypothalamic corticotropin-releasing hormone (CRH) release, which in turn activates the pituitary-adrenal axis

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Variations in electronic health record-based definitions of diabetic retinopathy cohorts: a literature review and quantitative analysis

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The approach included regular lifestyle counseling sessions delivered by a dietitian or a qualified health care professional to help the participants adhere to healthful, balanced meals with a moderate caloric deficit (e.g., 500 calories per day) and physical activity (e.g., at least 150 minutes of per week) (250, 253), often with the help of basic behavior procedures such as the daily recording the diet and activity within a diary or using a smartphone application (253)

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Furthermore, this financial obstacle prevents faster uptake despite recognized clinical benefits, predominantly in patient segments with low to intermediate incomes

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