If glutathione stores are depleted or overwhelmed, then NAPQI can bind cellular proteins to form toxic byproducts that produce hepatotoxicity
They could also ease oxidative stress by mopping up chemically reactive oxygen molecules with an FDA-approved antioxidant called N-acetylcysteine, or NAC, thats already used to help treat children with cystic fibrosis
Other studies have found that taking glutathione at 250 or 1000 mg/day led to increased glutathione levels [37]
Jhun J, Woo JS, Lee SH, Jeong JH, Jung K, Hur W
These effects are mediated through downstream activation of transcription factors such as c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodeling, and angiogenic signaling [26]
Its annoying but manageable for most