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Sustained elevation of IGF-1 is associated, in observational studies of acromegaly (a disease of GH excess), with increased risk of several cancers including colorectal and breast

50 Next-Generation Modalities: Small Molecules and Poly-Agonists As the patent cliffs for current GLP-1 peptides approach, the industry is racing to develop next-generation assets that can achieve higher efficacy, better adherence, and refreshed IP protection

The medication needs time to build up, and the starting dose is intentionally conservative

doi: 10.1210/en.136.10.4629 39 ThorensBWidmannC

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Low protein leads to muscle loss, which lowers metabolic rate, which slows weight loss