In addition, PPG NTS neurons did not significantly suppress eating via GLP-1RA, although concurrent activation of the PPG NTS neuron had a higher effect in suppressing eating than semaglutide alone
And the big one that we think of it as is intestinal tract health
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While rare, several post-marketing reports and some large database studies suggest a possible increased risk of NAION associated with certain GLP-1 RAs, including semaglutide
Its clinical factor table says proton pump inhibitors and H2 blockers can be used alongside GLP-1 therapy if reflux emerges, and the safety section lists them plus dietary modification as parts of a gastroprotection plan