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GLP-1R signaling enhances glucose-dependent insulin secretion by activating of G s , upregulating of cAMP, and subsequently activating of PKA ( + efflux, repolarizing the cell and allowing increased calcium influx through voltage-dependent calcium channels, resulting in the exocytosis of insulin from -cells (115)

Amin, K

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Given the complexity of symptoms and the variety of possible causes, consulting a medical professional ensures an accurate diagnosis and appropriate treatment

Our data-gathering process includes: 2

These findings align with prior randomized trials and meta-analyses suggesting class-level cardiovascular benefit