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Arch.Toxicol

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Analysis based on publicly available information from the OzemPatches website, observed on December 26, 2025

Definition: damage to the myelin sheath of the white matter in the CNS caused by a sudden rise in serum osmolality Central pontine myelinolysis Most common type Affects the central region of the pons Extrapontine myelinolysis: can affect the cerebellum, lateral geniculate body, thalamus, putamen, cortical, and/or subcortical white matter Causes Iatrogenic: rapid correction of chronic hyponatremia High-risk factors for ODS: alcohol use disorder, malnutrition, liver disease, hypokalemia, initial sodium concentration 105 mEq/L [2] Rapid changes in other osmotically active solutes (e.g., glucose) Acute severe hypernatremia Clinical features [30] [31] Symptoms first develop several days after the correction of hyponatremia

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GLP-1 acts through its receptors, GLP-1R, which is expressed in different tissues, including the pancreas, heart, kidney, adipose, and central nervous system